The Italian Sub Grilled Cheese Sandwich Recipe is truly a game-changer when it comes to elevating your sandwich experience. Imagine the satisfying crunch of golden grilled bread packed with layers of savory salami, spicy pepperoni, creamy provolone, and a perfectly tangy, crisp iceberg lettuce salad all melted together in gooey harmony. This sandwich offers a delightful balance of textures and flavors that feels both comforting and exciting. Whether you’re craving a quick lunch or an indulgent snack, this recipe will quickly become your go-to favorite.

Ingredients You’ll Need
Gathering the right ingredients is the secret to creating an irresistible Italian Sub Grilled Cheese Sandwich Recipe. Each component plays a vital role in delivering the authentic flavors and perfect textures that make every bite memorable.
- Italian bread or sturdy white sandwich bread: The hearty foundation that crisps beautifully when grilled.
- Unsalted butter, softened: Adds golden crispiness and a rich, buttery flavor to the crust.
- Provolone cheese slices: Melts smoothly, providing creamy, mild sharpness that balances the meats.
- Salami slices: Offers a smoky, slightly spicy bite that’s classic in an Italian sub.
- Pepperoni slices: Adds a zesty kick and vibrant color to the sandwich layers.
- Shredded iceberg lettuce: Brings a crisp, refreshing crunch to offset the richness.
- Mayonnaise: Creates a luscious creaminess that holds the lettuce mixture together.
- Red wine vinegar: Injects a bright, tangy note that wakes up the palate.
- Dried oregano: Infuses an earthy, herbal aroma that echoes Italian flavors.
- Salt and freshly ground black pepper: Essential for seasoning and enhancing all the layers.
- Mild pepperoncini rings, drained: Adds a subtle tang and slight heat for extra zing.
- Thinly sliced red onion: Provides a sharp, sweet contrast to the savory meats.
How to Make Italian Sub Grilled Cheese Sandwich Recipe
Step 1: Prepare the Lettuce Mixture
Start by mixing shredded iceberg lettuce with mayonnaise, red wine vinegar, dried oregano, salt, and freshly ground pepper. This combination isn’t just a simple salad; it’s an essential component that adds freshness, creaminess, and a bright tang that perfectly complements the rich meats and melted cheese in your Italian Sub Grilled Cheese Sandwich Recipe.
Step 2: Butter the Bread Slices
Lay out four slices of your chosen bread and spread a generous, even layer of softened unsalted butter on one side of each slice. This butter will caramelize as you grill, creating that golden, crisp exterior that makes the sandwich so satisfyingly addictive.
Step 3: Layer the Base Sandwich Components
Place two bread slices butter-side down. Start layering each with two slices of provolone cheese, followed by three slices of salami and then three slices of pepperoni. This meat and cheese trio is the heart of the sandwich, introducing bold flavor and creamy meltiness.
Step 4: Add Optional Toppings
Distribute the pepperoncini rings and thinly sliced red onion evenly atop the meats and cheese on each sandwich base. These toppings add an unexpected pop of sharpness and gentle heat that enhances every bite, taking this sandwich beyond the ordinary.
Step 5: Add the Lettuce Mixture
Spread the previously prepared lettuce mixture generously over the meat and cheese layers. This step brings the essential crunch and tang that transforms this grilled sandwich into a vibrant Italian sub experience.
Step 6: Complete the Sandwiches
Top each sandwich with the remaining two bread slices, butter-side up. This final bread layer seals in all the delicious fillings, ready to be grilled to perfection.
Step 7: Grill the Sandwiches
Preheat a large skillet or grill pan over medium heat. Place the sandwiches in the pan and cook for about 3 to 4 minutes on each side, pressing gently with a spatula to ensure even grilling. You’re looking for golden brown bread with the cheese melted to a luscious ooze inside.
Step 8: Finish and Serve
Remove the sandwiches from the heat and slice each diagonally in half. Serve immediately while warm and enjoy the full, gooey, crunchy, and tangy symphony of flavors in every bite of this Italian Sub Grilled Cheese Sandwich Recipe.
How to Serve Italian Sub Grilled Cheese Sandwich Recipe

Garnishes
Add a few fresh oregano sprigs or basil leaves on top when plating to bring an aromatic finishing touch that mirrors the Italian-inspired flavors inside. A light dusting of cracked black pepper on the cut edges also adds a subtle kick and appealing rustic look.
Side Dishes
This hearty sandwich pairs wonderfully with crispy kettle-cooked potato chips or a simple side salad dressed in an Italian vinaigrette. Alternatively, a cup of tomato soup complements the cheesy indulgence and adds warmth to your meal.
Creative Ways to Present
Try serving your Italian Sub Grilled Cheese Sandwich Recipe on a wooden board with small bowls of pepperoncini rings and extra red onions for a fun, interactive experience. Wrapping the sandwiches in parchment paper and securing with a rustic string makes a charming presentation for a casual lunch picnic or gathering.
Make Ahead and Storage
Storing Leftovers
If you have leftovers, wrap them tightly in foil or plastic wrap and refrigerate for up to 2 days. To keep the bread from getting soggy, let the sandwich cool completely before wrapping.
Freezing
You can freeze the sandwiches before grilling by wrapping them well in plastic and placing in an airtight container or freezer bag. Freeze for up to 1 month. When ready, thaw overnight in the fridge before grilling for a fresh, toasty experience.
Reheating
For reheating, place the sandwich in a skillet over medium-low heat and toast gently on both sides until warmed through and the cheese melts again. Avoid microwaving to keep the bread crispy and delicious.
FAQs
Can I use different cheeses in this Italian Sub Grilled Cheese Sandwich Recipe?
Absolutely! While provolone is classic and melts beautifully, mozzarella or Fontina would also work well if you want a creamier or slightly different flavor profile.
Is this sandwich good for making ahead of time?
Yes, you can assemble the sandwiches and prepare the lettuce mixture in advance, but it’s best to grill them just before serving to maintain that perfect crispy texture and melty cheese.
Can I make this sandwich vegetarian?
Definitely! Swap the salami and pepperoni for grilled vegetables like zucchini, roasted red peppers, and mushrooms to still enjoy a rich and flavorful grilled cheese with an Italian twist.
What if I don’t have red wine vinegar?
Red wine vinegar adds a signature tang, but you can substitute with apple cider vinegar or white wine vinegar in equal amounts, though the flavor will be a bit milder.
How spicy is this sandwich?
The sandwich has a mild to medium spice level due to the pepperoncini and pepperoni. You can adjust by adding more or fewer pepperoncini rings or choosing a milder or spicier pepperoni.
Final Thoughts
When you try this Italian Sub Grilled Cheese Sandwich Recipe, you are in for a wonderfully delicious, satisfying meal that feels both familiar and exciting. The layers of melted cheese and bold Italian meats, paired with the tangy lettuce mixture and perfectly grilled bread, create a sandwich experience that you’ll keep coming back to again and again. Don’t hesitate to make it soon and share it with friends because it truly is a warm hug on a plate.
Print
Italian Sub Grilled Cheese Sandwich Recipe
- Prep Time: 10 minutes
- Cook Time: 10 minutes
- Total Time: 20 minutes
- Yield: 2 sandwiches
- Category: Sandwich
- Method: Frying
- Cuisine: Italian-American
Description
A deliciously satisfying Italian Sub Grilled Cheese Sandwich featuring layers of provolone, salami, pepperoni, fresh shredded lettuce mixed with a tangy dressing, pepperoncini, and red onion, all sandwiched between buttered Italian bread and grilled to golden perfection. Perfect for a quick and flavorful lunch or dinner.
Ingredients
Bread and Butter
- 4 slices Italian bread or sturdy white sandwich bread
- 2 tablespoons unsalted butter, softened
Cheese and Meats
- 4 slices provolone cheese
- 6 slices salami
- 6 slices pepperoni
Lettuce Mixture
- 1 cup shredded iceberg lettuce
- 2 tablespoons mayonnaise
- 1 tablespoon red wine vinegar
- 1 teaspoon dried oregano
- Salt and freshly ground black pepper to taste
Additional Toppings
- 2 tablespoons mild pepperoncini rings, drained
- 2 tablespoons thinly sliced red onion
Instructions
- Prepare Lettuce Mixture: In a mixing bowl, combine shredded iceberg lettuce, mayonnaise, red wine vinegar, dried oregano, salt, and freshly ground black pepper. Mix thoroughly until the lettuce is evenly coated and set aside.
- Butter Bread Slices: Lay out all four bread slices on a clean work surface. Spread one side of each slice evenly with softened butter.
- Layer Base Sandwich Components: Place two buttered bread slices butter-side down on the work surface. Top each slice with 2 slices of provolone cheese, followed by 3 slices of salami and 3 slices of pepperoni in order.
- Add Optional Toppings: Evenly distribute the drained pepperoncini rings and thinly sliced red onion over the meat and cheese layers on each sandwich base.
- Add Lettuce Mixture: Spread the prepared lettuce mixture evenly over the meats and cheese on each sandwich base to add freshness and tang.
- Complete Sandwiches: Top each sandwich with a remaining slice of bread, butter-side up, to close the sandwich.
- Grill Sandwiches: Heat a large skillet or grill pan over medium heat. Place the sandwiches in the pan and cook for 3 to 4 minutes per side, pressing gently with a spatula to ensure even grilling, until the bread is golden brown and the cheese is fully melted.
- Finish and Serve: Remove the sandwiches from the heat, slice each in half diagonally, and serve immediately while hot for the best taste and texture.
Notes
- Using Italian bread adds authentic flavor, but sturdy white sandwich bread works well too.
- Make sure the butter is softened for easy spreading on the bread slices.
- Adjust the amount of pepperoncini and onion to your preference or omit if you prefer a milder flavor.
- Press sandwiches gently while grilling to help the cheese melt evenly and to compact the sandwich for easier eating.
- This sandwich is best served fresh and hot straight from the skillet for optimal crispiness and melted cheese.

